A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation
نویسندگان
چکیده
منابع مشابه
Ueda et al, Trafficking-defective HCN4 mutation in cardiac arrhythmia - 1 - Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia Running title: Trafficking-defective HCN4 mutation in cardiac arrhythmia
1 Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia Running title: Trafficking-defective HCN4 mutation in cardiac arrhythmia Kazuo Ueda, Kazufumi Nakamura, Takeharu Hayashi, Natsuko Inagaki, Megumi Takahashi, Takuro Arimura, Hiroshi Morita, Yasushi Higashiuesato, Yuji Hirano, Michio Yasunami, Shuichi Takishita, Akira Yamashina, Tohru...
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Atrial fibrillation (AF) is the most common arrhythmia in the clinic. While previous studies have identified AF-associated mutations in several genes, the genetic basis for AF remains unclear. Here, we identified a novel T361S missense mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) from a Chinese Han family ancestor with lone AF. The wild-type (WT) or muta...
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AIMS Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in KV4.3 or in the auxiliary s...
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Cardiovascular complications remain the major problems contributing to morbidity and mortality in patients with polycystic kidney disease (PKD). Therefore, the authors hypothesized that atrial fibrillation (AF) is closely associated with PKD. The authors conducted a nationwide population-based cohort study to investigate the risk of AF in patients with PKD. Using data from inpatient claims, the...
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BACKGROUND Familial sick sinus syndrome (SSS) is often attributable to mutations in genes encoding the cardiac Na channel SCN5A and pacemaker channel HCN4. We previously found that SSS with SCN5A mutations shows early onset of manifestations and male predominance. Despite recent reports on the complications of atrial fibrillation (AF) and left ventricular noncompaction (LVNC) in patients with S...
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2014
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2014.03.002